What is the definition of necrosis?

Necrosis is defined as cell death that occurs as a result of injury, inflammation, or ischemia, which refers to a lack of blood supply to tissues. This type of cell death is typically uncontrolled and can lead to inflammation and damage to surrounding tissues. In contrast to normal physiological processes, such as apoptosis (the programmed cell death), necrosis is often associated with pathological conditions where cells suffer significant injury from external factors, such as toxins, trauma, or inadequate blood flow.

In cases of necrosis, the cellular structures break down in a way that can lead to an inflammatory response, further complicating the healing process. This mechanism underscores why necrosis is an important concept in understanding tissue damage and the body's response to injury, particularly in clinical settings.

The other definitions do not capture the critical elements that define necrosis, such as the context of injury and the inflammatory response. Understanding necrosis is vital for healthcare professionals in diagnosing conditions and developing treatment plans for patients experiencing significant tissue damage.